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Using NMR and X-ray crystallography we are currently characterizing the interactions of Smad proteins and cofactors with DNA promoters, to provide a first understanding of how these molecular machines work and to pave the basis for the design of small molecular inhibitors specifically targeted towards tumor-derived Smad forms. Structural characterization of macromolecular assemblies. IRB Barcelona - Institute for Research in Biomedicine, 01B41.
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